Rabbit polyclonal LGR5 Antibody validated in IHC to detect human small intestine, colon, colon cancer, liver cancer tissues. Referenced in 3 publications. View extensive LGR5 antibody validation data and order now for free next day delivery. $99 trial size samples available.
LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients2019Ingår i:
Lgr5. Gene Synonyms. FEX， Gpr49. Human Ortholog.
The study of stem cell–enriched genes has uncovered some previously unknown aspects of the Wnt signaling pathway, the major driver of crypt dynamics. LGR5+ stem cells Human Lgr5/GPR49 Antibody Provider product page R&D Systems - MAB8078 Antibody type Monoclonal Description Protein A or G purified from hybridoma culture supernatant. Detects human Lgr5/GPR49 in ELISA. Stains human and mouse Lgr5 transfected cells but not irrelevant transfectants in Flow Cytometry and Immunocytochemistry. Lgr5+ ISC function during homeostasis and injury repair to investigate whether Lgr5 and Bmi1 mark identical, similar, or distinct ISC populations. Results Bmi1 Marks Quiescent ISCs That Contribute Minimally to Intestinal Homeostasis.
Lgr5 was most exclusively expressed in cells intermingled with Paneth cells. Olfm4, Lrig1 and Hopx were enrichedat the bottom of crypts, but the expression gradient extended to varying degrees above the Paneth cell compartment. Tert and Bmi1 appeared expressed at similar low levels throughout the crypt with the inclusion of the Paneth cell zone.
Paneth cells Plasmid HR180-LGR5-iCT from Dr. Toshiro Sato's lab contains the insert iCaspase9-T2A-tdTomato and LGR5 homology arms and is published in Nature. 9 May 2019 Furthermore, Lgr5 may be a potential target gene for overcoming Dox resistance. Keywords: Lgr5, PDCD5, hepatocellular carcinoma, resistance Leucine-rich repeat-containing G protein–coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most notably in the 31 Aug 2019 Gene: LGR5; leucine rich repeat containing G protein-coupled receptor 5.
Lgr5 binds and forms complexes with R‑Spondins, Frizzled Wnt receptors and LRP Wnt co‑receptors. The region of the mouse Lgr5 long extracellular domain used as an immunogen shares 90% and 95% amino acid sequence identity with human and rat Lgr5, respectively. Lgr5 is found on embryonic and adult epithelial stem cells (3).
These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues. LGR5 (inglise Leucine-rich repeat-containing G-protein coupled receptor 5) ehk leutsiinirikkaid kordusi sisaldava G-valguga seotud retseptor 5 (LGR5) (tuntakse samuti kui G-valguga seotud retseptor 49 (GPR49) või G-valguga seotud retseptor 67 (GPR67)) on valk, mille kodeerib on inimestel LGR5 geen. Cell atlas. Showing subcellular location of LGR5 (FEX, GPR49, GPR67, HG38).
Supplied as 100 µL purified antibody (1 mg/mL). 2019-12-31
View our 41 Lgr5/GPR49 products for your research including Lgr5/GPR49 Primary Antibodies, cDNA Clones, and Proteins and Enzymes.
Marsipan format
$99 trial size samples available.
Within this GPCR superfamily
28 May 2020 The stem cell marker Lgr5 is part of a feedback loop allowing fine‐tuning of Wnt signaling in intestinal stem cells during late fetal and postnatal
Invitrogen Anti-LGR5 Monoclonal (OTI2A2), Catalog # MA5-25644. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry ( Paraffin)
15 Jul 2020 This study has been designed to determinate clinical implications of CSC markers: CD44, DCLK1, Lgr5, and ANXA2 in CRC.
Heterozygous mice harbor an Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 gene function and expresses EGFP and CreERT2 fusion
Rabbit recombinant monoclonal LGR5 antibody [EPR3065Y].
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Invitrogen Anti-LGR5 Monoclonal (OTI2A2), Catalog # MA5-25644. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry ( Paraffin)
Leucine rich repeat containing G protein-coupled receptor 5) – білок , який кодується однойменним геном, розташованим у людей на короткому Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target 13 Nov 2019 While Lgr5 deletion at the time of V(D)J recombination resulted in near complete ablation of the B cell lineage in the bone marrow and periphery, Detects mouse Lgr5/GPR49 in direct ELISAs. Stains mouse Lgr5 transfected cells but not irrelevant transfectants in Flow Cytometry. Order Information. Stains mouse Lgr5 transfected cells but not irrelevant transfectants in Flow Cytometry and Immunocytochemistry. This antibody, also known as "RD20", has been 12 Nov 2019 LGR5 is found on Wnt/β-catenin-dependent adult stem cells of the colon and regulates Wnt signaling to R-spondin receptors [12].
Description: - High air flow with exceptional filtration. - Fitment for KYMCO LIKE 17211-LGR5-E000 LX 125 2009-2012. - Allows more air to flow easily to the
Referenced in 3 publications. View extensive LGR5 antibody validation data and order now for free next day delivery. $99 trial size samples available. LGR5 A gene on chromosome 12q22-q23 that encodes an orphan G protein-coupled receptor that is the stem cell marker of the intestinal epithelium and hair follicles. LGR5 is the target gene of Wnt signalling.
Gene Symbol. Lgr5. Gene Synonyms. FEX， Gpr49. Human Ortholog. LGR5. Ensembl ID. ENSMUSG00000020140.